Adolescence is a crucial phase of life. This is the phase for planning the future and the formation of self. concepts; as well as self-esteem. This study is aimed to determine the relationship between self-esteem and the purpose in life of the adolescents. The study was conducted by distributing Self-questionnaire and the purpose in life scalè to 210 young people, unmarried; aged 11 to 24; according to the age limit of adolescent in Indonesia. This study is a correlational study, trying to find out the correlation of self-esteem and purpose in life. The results of this study indicate there is a significant positive relationship between self-esteem with the purpose in life of the adolescent with a correlation coefficient of r # 0.625 ( p 0.000 ) , while the contribution of self - esteem to purpose in life is 39 % . This result indicate that the seif-esteem gives a significant contribution in determine the purpose in life.