Detail Inovasi Perguruan Tinggi


Tema: International Seminar on Natural products Chemistry (ISNPC) 2018
Judul: In Vivo Antimalarial Activities of Combination Water Extract of Coat Buttons Herbal (Tridax procumbens L) and Neem Leaves (Azadirachta Indica A. JUSS)
Perguruan Tinggi: Universitas Jenderal Achmad Yani
Jenis/sdm: dosen/0412108203

Tahun: 2018

Malaria is still a health problem both in the world and in Indonesia. This is exacerbated by malaria parasites (Plasmodium) that are resistant to existing antimalarial drugs. Some of the plants used for the treatment of malaria are coat buttons herbs (Tridax procumbens L.) and neem leaves (Azadirachta indica A. Juss). This study aims to assess the antimalarial activity of a combination of coat buttons herbs and neem leaves extract on Plasmodium berghei. The antimalarial activity test in this study was conducted according to Peters method. Mice infected with Plasmodium berghei were then grouped into several groups. The control group was given by 0.5% Na CMC suspension, the standard group was given by chloroquin 20 mg/kg BW and the test group was given by a combination of extract of coat buttons herbal dose 400 mg/Kg BW and water extract of mimba leaves with dose of 200 mg/kg BW; a combination of extract of coat buttons herbal with dose of 800 mg/Kg BB and water extract of mimba leaves with dose of 400 mg/kg BW; a combination of extract of coat buttons herbal with dose of 1600 mg/Kg BB and water extract of mimba leaves with dose of 800 mg/kg BW with parameter percentage of parasitemia, percent parasite growth and percentage inhibition parasite. The results showed that all combined doses showed a decrease in parasite growth when compared with the control group (P <0.05). The percentage value of parasite inhibit of combination of 1,2 and 3 doses, respectively was 40%: 65%; 35%. The combination of extract of coat buttons herbal with dose of 800 mg/Kg BW and water extract of mimba leaves with dose of 400 mg/kg BW has the highest antimalarial activity with a percentage of parasite inhibition of 65% Keywords: Plasmodium berghei, Azadirachta indica A. Juss, Tridax procumbens L., Malaria